Table 1. Overall and Subtype-Specific Breast Cancer Mortality Reductions in 2012 Associated With Screening, Treatment, or Both by Modela.
Model | Mortality Reduction, %b | Fraction of Combined Mortality Reduction, % | Relative Contribution to Combined Mortality Reduction, %c | ||||
---|---|---|---|---|---|---|---|
Associated With Screening Alone | Associated With Treatment Alone | Associated With Screening and Treatmentd | Associated With Screening Alonee | Associated With Treatment Alonef | Associated With Screeningg | Associated With Treatmenth | |
Overall | |||||||
Dana-Farber | 29 | 28 | 49 | 59 | 57 | 51 | 49 |
Erasmus | 18 | 30 | 43 | 41 | 70 | 37 | 63 |
Georgetown-Einstein | 25 | 37 | 53 | 47 | 69 | 40 | 60 |
MD Anderson | 17 | 29 | 39 | 44 | 73 | 38 | 62 |
Stanford | 18 | 37 | 50 | 36 | 74 | 33 | 67 |
Wisconsin-Harvard | 17 | 49 | 58 | 30 | 84 | 26 | 74 |
Mean | 21 | 35 | 49 | 43 | 71 | 37 | 63 |
By Molecular Subtype | |||||||
ER+/ERBB2− | |||||||
Dana-Farber | 30 | 30 | 52 | 59 | 58 | 50 | 50 |
Erasmus | 18 | 34 | 46 | 39 | 73 | 35 | 65 |
Georgetown-Einstein | 26 | 39 | 54 | 48 | 71 | 40 | 60 |
MD Anderson | 17 | 31 | 42 | 42 | 75 | 36 | 64 |
Stanford | 19 | 41 | 53 | 35 | 77 | 31 | 69 |
Wisconsin-Harvard | 16 | 51 | 59 | 27 | 86 | 24 | 76 |
Mean | 21 | 38 | 51 | 42 | 73 | 36 | 64 |
ER+/ERBB2+ | |||||||
Dana-Farber | 27 | 38 | 57 | 46 | 67 | 41 | 59 |
Erasmus | 20 | 42 | 52 | 39 | 82 | 32 | 68 |
Georgetown-Einstein | 24 | 43 | 58 | 41 | 74 | 36 | 64 |
MD Anderson | 18 | 38 | 46 | 38 | 82 | 32 | 68 |
Stanford | 17 | 58 | 66 | 26 | 88 | 23 | 77 |
Wisconsin-Harvard | 19 | 62 | 71 | 26 | 87 | 23 | 77 |
Mean | 21 | 47 | 58 | 36 | 80 | 31 | 69 |
ER−/ERBB2+ | |||||||
Dana-Farber | 25 | 28 | 49 | 52 | 58 | 47 | 53 |
Erasmus | 17 | 28 | 41 | 40 | 68 | 37 | 63 |
Georgetown-Einstein | 25 | 32 | 52 | 48 | 62 | 43 | 57 |
MD Anderson | 15 | 23 | 33 | 45 | 70 | 39 | 61 |
Stanford | 17 | 25 | 40 | 42 | 63 | 40 | 60 |
Wisconsin-Harvard | 23 | 43 | 55 | 41 | 79 | 34 | 66 |
Mean | 20 | 30 | 45 | 45 | 67 | 40 | 60 |
ER−/ERBB2− | |||||||
Dana-Farber | 26 | 20 | 40 | 66 | 50 | 57 | 43 |
Erasmus | 17 | 22 | 35 | 47 | 64 | 43 | 57 |
Georgetown-Einstein | 24 | 29 | 46 | 53 | 63 | 45 | 55 |
MD Anderson | 18 | 14 | 27 | 65 | 52 | 56 | 44 |
Stanford | 18 | 17 | 33 | 53 | 50 | 52 | 48 |
Wisconsin-Harvard | 18 | 30 | 42 | 43 | 70 | 38 | 62 |
Mean | 20 | 22 | 37 | 55 | 58 | 48 | 52 |
Abbreviations: ER, estrogen-receptor; ERBB2; human epidermal growth factor receptor 2.
The column labels are defined as follows:
Relative to the estimated baseline mortality in 2012.
These columns sum to 100%.
Combined mortality reduction.
Column 2 divided by column 4.
Column 3 divided by column 4.
Column 2 divided by the sum of columns 2 and 3.
Column 3 divided by the sum of columns 2 and 3.