Table 3.
Univariate and multivariate analysis of clinicopathological factors for overall survival of ESCC patients in the validation cohort
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | p value | HR (95%CI) | p value | |
| Gender (male/female) | 1.717 (0.942–3.128) | 0.074 | ||
| Age (≤60/>60) | 1.034 (0.619–1.726) | 0.900 | ||
| Size (cm) (≤5/>5) | 1.247 (0.765–2.030) | 0.375 | ||
| Differentiation (poor+others/well+moderate) | 1.351 (0.741–2.463) | 0.324 | ||
| Lymphatic invasion (present/absent) | 2.843 (1.414–5.716) | 0.002** | 1.976 (0.946–4.128) | 0.070 |
| Nerve invasion (present/absent) | 1.265 (0.910–1.757) | 0.160 | ||
| Tumor grade (T1, T2/T3, T4) | 1.386 (0.841–2.285) | 0.198 | ||
| LNM (present/absent) | 2.329 (1.338–4.053) | 0.002** | ||
| Distant metastasis (present/absent) | 1.884 (0.964–3.681) | 0.059 | ||
| TNM (I+II/ III+IV) | 2.660 (1.590–4.449) | 0.000** | 2.341 (1.343–4.080) | 0.003** |
| RAP80 (high/low) | 2.142 (1.256–3.652) | 0.004** | 2.239 (1.358–3.995) | 0.002** |