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. 2018 Jan 24;7(1):7. doi: 10.1038/s41389-017-0022-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative genitourinary organs. Ebag9KO mice were crossed with TRAMP mice to generate Ebag9KO;TRAMP(+) and control Ebag9WT;TRAMP(+) mice. Genitourinary organs were dissected from these male mice at 1 year old. Scale bar, 1 cm. b Prostate tumor development was repressed in Ebag9KO;TRAMP(+) mice. Genitourinary organ weight was measured at 1 year old. c Upregulation of Cd8 mRNA in prostate tumors generated in Ebag9KO;TRAMP(+) mice. qRT-PCR analysis of Cd8 mRNA was performed using RNAs from prostate tumors. The data are shown as mean ± SD (Ebag9KO;TRAMP(+), n = 10; Ebag9WT;TRAMP(+), n = 17). *P < 0.05 (two-sided Student’s t-test)