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. 2018 Feb 14;9(2):249. doi: 10.1038/s41419-018-0286-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Validation of let-7c expression in TFK-1 cells following treatment with mimic. b overexpressed let-7c inhibited invasive capacity of TFK-1 cells. Decreased migration and invasion in TFK-1 cells with upregulated let-7c expression. Numbers of (c) migrating and (d) invading cells. e Wound-healing assay with transfected TFK-1 cells. f The extent of gap closure in wound-healing assay showing. **P < 0.01. BC blank control group; NC negative control group; 7C+ let-7c-upregulated group