Fig. 1. ANXA3 is upregulated in breast cancer tissues and correlated with poor overall survival.

a The mRNA expression level of ANXA3 was examined in clinical breast tumor tissues and paratumor tissues by qRT-PCR. The two connected dots represent the ANXA3 levels in the tumor and paratumor from the same patient (n = 16). **p < 0.01. b The ANXA3 protein level in clinical breast tumor tissues and paratumor tissues are shown by immunohistochemistry (Brown: ANXA3). c Kaplan–Meier survival curves of breast cancer patients (log-rank test, ***p < 0.001), data from the Oncomine database (n = 471). d The ANXA3 protein level was measured in several breast cancer cell lines by western blotting