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. 2018 Feb 2;9(2):148. doi: 10.1038/s41419-017-0182-5

Fig. 3. USP4 promoted HCC cell growth and intrahepatic metastasis in vivo.

Fig. 3

a USP4 knockdown suppressed HCC cell tumorigenesis in vivo (n = 6). The volume of subcutaneous tumors was measured. b IHC staining of xenograft tumors for the cell proliferation biomarker, Ki-67, derived from MHCC97H-shUSP4 cells and control cells. Representative images are shown. c Representative images of intrahepatic metastatic nodules derived from stable MHCC97H-shUSP4 cells and control cells are shown (n = 6). d USP4 overexpression promoted cell tumorigenesis in vivo (n = 6). e Representative images of IHC staining of xenograft tumors for Ki-67 derived from Huh7-USP4 cells and control cells are shown. Error bars represent the SD. *P < 0.05; **P < 0.01; ***P = 0.000. Scale bars: 100μm