Table 2.

Univariate and multivariate Cox proportional hazards model for overall survival and postoperative cumulative recurrence

	Overall survival				Cumulative recurrence
	Univariate		Multivariate		Univariate		Multivariate
Factors	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
Sex (female vs. male)	0.507 (0.202−1.271)	0.147	−	−	0.575 (0.174−1.895)	0.363	−	−
Age, years (>50 vs. ≤50)	0.627 (0.378−1.066)	0.085	−	−	0.616 (0.297−1.278)	0.193	−	−
Tumor differentiation (III/IV vs. I/II)	2.140 (1.194−3.835)	0.011	1.300 (0.682−2.479)	0.425	2.094 (0.919−4.768)	0.078
Tumor encapsulation (absent vs. present)	0.957 (0.551−1.662)	0.877	−	−	1.295 (0.622−2.695)	0.489	−	−
Tumor size (diameter, cm) (>5 vs. ≤5)	5.483 (3.002−10.014)	<0.001	3.412 (1.733−6.718)	<0.001	7.086 (2.778−18.069)	<0.001	4.119 (1.491−11.380)	0.006
Tumor number (multiple vs. single)	1.597 (0.893−2.856)	0.114	−	−	1.126 (0.481−2.639)	0.784	−	−
Vascular invasion (yes vs. no)	4.915 (2.769−8.724)	<0.001	4.554 (2.429−8.536)	<0.001	10.266 (3.829−27.522)	<0.001	8.706 (2.977−25.458)	<0.001
Liver cirrhosis (yes vs. no)	0.763 (0.452–1.289)	0.312	−	−	0.697 (0.339−1.433)	0.327	−	−
HBsAg (+ vs. −)	1.083 (0.463−2.534)	0.853	−	−	0.805 (0.280−2.317)	0.687	−	−
Serum AFP, ng/mL (>20 vs. ≤20)	2.739 (1.425−5.262)	0.002	1.403 (0.649−3.033)	0.389	3.900 (1.340−11.355)	0.013	2.168 (0.656−7.157)	0.204
Serum ALT, U/L (>75 vs. ≤75)	2.062 (0.926−4.594)	0.077	−	−	1.860 (0.646−5.361)	0.250	−	−
Serum TB, μmol/L (>17 vs. ≤17)	0.585 (0.311−1.099)	0.095	−	−	0.490 (0.198−1.212)	0.122	−	−
USP4 expression (high vs. low)	4.076 (2.106−7.887)	<0.001	3.099 (1.510−6.357)	0.002	4.802 (1.760−13.099)	0.002	3.354 (1.123−10.031)	0.030

CI confidence interval, HR hazard ratio