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. 2018 Feb 20;9(3):299. doi: 10.1038/s41419-018-0361-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The proliferative rate of ALCAM⁺ cells isolated from clinical sapmles(cases #12, #17 and #21) was higher than that of ALCAM⁻ cells. Independent experiments were repeated three times. Data were presented as mean ± s.d. (***p < 0.001; **p < 0.01; *p < 0.05). b ALCAM⁻ cells isolated from GCTB samples (cases #22 and #30) generated fewer and smaller spheres than ALCAM⁺ cells after 7 days of serum deprivation and ultralow adherent cell culture. (Scale bar = 20 µm). c, d Compared with ALCAM^- cells from GCTB samples(cases #45 and #49), ALCAM⁺ cells exhibited stronger (c) invasive and (d) migratory capacity. Ten high-power fields were selected for comparison. Data were presented as mean ± s.d. (***p < 0.001; **p < 0.01; *p < 0.05; Scale bar = 50 µm)