Fig. 7. NBT inhibited the growth of MCF-7 solid tumor in a MCF-7 mouse xenograft model.

a Average tumor volume of MCF-7 xenografts in vehicle model mice and mice treated with NBT (100 mg/kg), BT (100 mg/kg), or 5-FU (22 mg/kg) for 11 days. ^*P < 0.05, vs. control group. b Body weight of mice during 11 days of exposure. Statistical analysis showed no significant differences in body weight changes. c Coefficient of the heart, liver, spleen, and kidney to the body weight of mice after 11 days of exposure. Statistical analysis showed no significant differences. d H&E staining and TUNEL assay for examining histological morphology and apoptosis. Representative images are shown at ×400 magnification. Scale bar: 100 μm. Data represent mean ± SD of three independent experiments