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. 2018 Jan 24;9(2):92. doi: 10.1038/s41419-017-0134-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Western blot analysis of YAP1 and CTGF in the rescue experiments. b YAP1 overexpression promoted cell proliferation compared with Empty vector control. Concordantly, YAP1 re-expression in AGS and MGC-803 cells enhanced proliferation in the presence of miR-375 (*, P < 0.05; **, P < 0.001). c Monolayer colony formation assays revealed that YAP1 overexpression or re-expression promoted colony formation compared with Empty vector control or miR-375 alone group respectively (**, P < 0.001). d The impaired cell invasive ability was partly restored in YAP1 re-expression group compared with a miR-375 alone group (**, P < 0.001). e In xenograft formation assay by MGC-803 cells, YAP1 re-expression promoted xenograft formation compared with miR-375 alone group (*, P < 0.05)