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. 2018 Jan 18;9(2):33. doi: 10.1038/s41419-017-0040-5

Fig. 4. DEPs associated with DOT1L inhibition are related to OC differentiation, mainly in pre-OCs.

Fig. 4

RAW264.7 cells pretreated with DMSO or the DOT1L inhibitor EPZ5676 were stimulated with RANKL for the indicated times. RAW264.7 cells pretreated with DMSO or the DOT1L inhibitor EPZ5676 for the indicated times without RANKL stimulation were used as controls. a Experimental flowchart of tandem mass tag-based quantitative proteomics and subsequent analysis. b Venn diagram of DEPs in RAW264.7 cells and pre-OCs after 40-h treatment. c Venn diagram of DEPs in RAW264.7 cells and pre-OCs/OCs after 60-h treatment. d Venn diagram of DEPs in pre-OCs (40-h and 60-h) and OCs. DEPs, differentially expressed peptides