Fig. 5. GO biological processes and KEGG pathways analysis of DOT1L inhibitor-induced OC-related DEPs.

DEPs were identified via proteomic approaches based on tandem mass tag-labeling in three stages of OC differentiation induced by DOT1L inhibitor for the indicated times: 40-h pre-OCs, 60-h pre-OCs, and 60-h OCs. DEPs were submitted to the DAVID online GO classification system and KEGG pathway analysis (http://david.ncifcrf.gov/). The enrichment significance (-log10 [P-value]) threshold is P < 0.05. The six most-enriched categories are shown if more than six categories exceed the threshold. a–c Analysis of upregulated proteins and downregulated proteins in a 40-h pre-OCs, b 60-h pre-OCs, and c 60-h OCs. d KEGG pathway analysis of DEPs in 40-h pre-OCs, 60-h pre-OCs, and 60-h OCs. GO: gene ontology, KEGG: Kyoto Encyclopedia of Genes and Genomes, DEPs: differentially expressed proteins