Table 4.
Serotype distribution, CIP MICs, topoisomerases and PMQR genes, and β-lactamase genes of 26 CIP-resistant isolates
| Serotypes | No. of isolates | Source (n) | MIC (μg/mL)
|
ESBL | gyrA | parC | PMQR | β-lactamase | |
|---|---|---|---|---|---|---|---|---|---|
| CIP | Cefotaxime | ||||||||
| Indiana | 6 | Water (4), feces (2) | >32 | >128 | Yes | S83F, D87N | S80R | qnrB, aac(6′)-Ib-cr | OXA, CTX-M |
| Typhimurium | 4 | Food (2), feces (2) | 2–4 | 128 | Yes | – | S80R | qnrB, qnrS | CTX-M |
| Typhimurium | 2 | Feces (2) | 2–4 | 64 | Yes | D87N | WT | qnrB, aac(6′)-Ib-cr | OXA |
| Agona | 2 | Feces (1), food (1) | 2–4 | 64 | Yes | S(TCC)83S(TCT) | WT | qnrB | TEM |
| Derby | 5 | Feces (5) | 2 | 64 | Yes | S(TCC)83S(TCT) | WT | qnrB, qnrS, aac(6′)-Ib-cr | OXA, TEM |
| London | 3 | Feces (3) | 2 | <1 | No | – | WT | qnrB, aac(6′)-Ib-cr | – |
| Rissen | 1 | Blood (1) | 2 | 4 | No | – | WT | qnrB | TEM |
| Corvallis | 1 | Feces (1) | 2 | <1 | No | – | WT | qnrB + qnrS | – |
| Kentucky | 1 | Food (1) | 16 | 64 | Yes | S83F, D87G | S80R | qnrB | CTX-M |
| Hadar | 1 | Feces (1) | 2 | <1 | No | – | WT | qnrB | – |
Abbreviations: CIP, ciprofloxacin; MIC, minimal inhibitory concentration; PMQR, plasmid-mediated quinolone resistance; ESBL, extended-spectrum β-lactamase; WT, wild type.