Table 5.
Prevalence of genetic determinants related to quinolone resistance in CIP-resistant isolates and in 100 reduced CIP-susceptible isolates
| Gene | Reduced CIP-susceptible isolates (n=100), % | CIP-resistant isolates (n=26), % | Pa | |
|---|---|---|---|---|
| PMQR gene | qnrA | 5 (5) | – | – |
| qnrB | – | 26 (100) | <0.001* | |
| qnrS | 20 (20) | 10 (38) | 0.14 | |
| aac(6′)-Ib-cr | 15 (15) | 16 (62) | <0.001* | |
| gyrA mutation | S83F | 8 (8) | 7 (27) | – |
| S(TCC)83S(TCT) | – | 7 (27) | – | |
| D87N | 6 (6) | 8 (31) | – | |
| D87Y | 4 (4) | – | – | |
| D87G | – | 1 (4) | – | |
| Event/isolate | 0.18 | 0.88 | <0.001* |
Notes:
a
P value between reduced CIP-susceptible and CIP-resistant isolates.
*
Statistically significant.
Abbreviations: CIP, ciprofloxacin; PMQR, plasmid-mediated quinolone resistance.