Table 1.
Summary of the targetable tumor antigens selected for CAR-T cell-based immunotherapy in epithelial malignancies (from http:/clinicaltrials.gov)
| Target antigen | Disease tumor | CAR-T | Gene transfer | Reference | Identifier |
|---|---|---|---|---|---|
| CEA | Colorectal carcinoma | CD28/CD3ζ | LV/RV | 94, 95 | NCT03267173—NCT00673322 |
| Breast cancer | NCT00673829—NCT02850536 | ||||
| Liver metastases | |||||
| EGFR | Glioma—NSCL cancer | 4-1BB/CD3ζ | LV | 96 | NCT03182816–NCT03152435 |
| NCT02331693–NCT01869166 | |||||
| EGFRvIII | Glioma—Glioblastoma | CD28/4-1BB/CD3ζ | LV/RV | 97, 98 | NCT03267173–NCT03170141 |
| NCT02844062–NCT02664363 | |||||
| NCT01454596 | |||||
| EphA2 | Glioma | NA | NA | NCT02575261 | |
| EpCAM | Carcinomasa | CD28/CD3ζ | LV | NCT03013712–NCT02729493 | |
| NCT02725125–NCT02915445 | |||||
| ErbB2 | Carcinomasb | CD28/CD3ζ | RV | 24, 47, 99, 100 | NCT03267173–NCT02713984 |
| NCT02547961–NCT01935843 | |||||
| FAP | Mesotelioma | CD28/CD3ζ | RV | 101 | NCT01722149 |
| FR-α | Ovarian carcinoma | FcεR1 γ | RV | 102 | NCT03185468–NCT00019136 |
| GD2 | Neuroblastoma | CD28/CD3ζ/OX40 | RV | 103, 104 | NCT03356795–NCT02919046 |
| NCT02765243–NCT02761915 | |||||
| NCT01822652 | |||||
| GPC3 | Lung squamous cell carcinoma | NA | NA | NCT03198546–NCT03084380 | |
| Hepatocellular carcinoma | NCT02905188–NCT02876978 | ||||
| NCT02723942–NCT02395250 | |||||
| IL13-Rα2 | Glioma | 4-1BB/CD3ζ | LV | 105 | NCT02208362 |
| Mesothelin | Metastatic cancer | 4-1BB/CD3ζ | LV/RV RNA-EP | 106 | NCT03356795–NCT03323944 |
| Pleural mesothelioma | NCT03267173–NCT03182803 | ||||
| Pancreatic carcinoma | NCT02930993–NCT02792114 | ||||
| Breast carcinoma | NCT02580747–NCT02465983 | ||||
| Lung cancer | NCT02388828–NCT01897415 | ||||
| NCT01583686 | |||||
| MUC1 | Carcinomasc | CD28/4-1BB/CD3ζ | LV | 107 | NCT03356808–NCT03356795 |
| NCT03267173–NCT03198052 | |||||
| NCT02617134–NCT02587689 | |||||
| MUC16 | Ovarian carcinoma | CD28/CD3ζ-IL-12 | NA | 108 | NCT02498912 |
| PSMA | Prostate cancer | CD28/CD3ζ | RV | 109 | NCT03185468–NCT03089203 |
| NCT01140373 | |||||
| ROR1 | Breast lung carcinoma | NA | NA | NCT02706392 | |
| VEGFR-II | Metastatic cancer | NA | RV | NCT01218867 | |
| Melanoma | |||||
| Renal cancer |
LV lentiviral, RV retroviral, NA not available
aGastric cancer—colon carcinoma—hepatocellular carcinoma—pancreatic carcinoma—prostate cancer—esophageal carcinoma
bGlioblastoma—glioma—sarcoma—head and neck squamous cell carcinoma—breast cancer—ovarian cancer—gastric cancer—lung cancer—pancreatic carcinoma
cGastric cancer—lung cancer—pancreatic carcinoma—breast cancer—glioma—colorectal carcinoma—hepatocellular carcinoma