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. 2018 Feb 8;9(2):201. doi: 10.1038/s41419-017-0190-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Representative bright field images showing PAS-positive glycogen granules in the frontal cortex region of autopsied brain tissues of subjects clinically diagnosed to have Alzheimer’s disease, Pick’s disease, or Parkinson’s disease as identified. The same regions of the brain were also immunostained with the SOD1 antibody, revealing increased levels of immunoreactivity. The panel below shows PAS and SOD1 immunoreactivity of the frontal cortex area of the two age-matched controls. These sections were from autopsied brain tissues of subjects who did not suffer from neurodegenerative conditions. Details on the subjects are given in the Supplementary Table S1. The PAS-positive glycogen granules shown here did not show autofluorescence, indicating they are not lipofuscin granules (scale bar, 10 µm)