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. 2018 Feb 7;9(2):178. doi: 10.1038/s41419-017-0200-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Gene Ontology analysis and classification of differentially expressed genes from control and RPE cells treated with 25 μM A2E under photosensitization into biological processes (top six). b Validation of the expression of the pro-inflammatory genes by RT-qPCR; ** indicates p value < 0.01, *** indicates p value < 0.001, **** indicates p value < 0.0001. The experiment was performed independently at least three times. c Heat map of genes related to SASP. d KEGG pathway analysis of significantly upregulated genes with 25 μM A2E under photosensitization. e Gene Ontology analysis and classification of significantly upregulated genes under 25 μM A2E with photosensitization into biological processes (top 10)