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. 2018 Feb 8;9(2):200. doi: 10.1038/s41419-017-0173-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a (upper panels) Whole-genome Hi-C heatmaps using 1-Mb bin of control (left) and ATRA-treated (right) HL-60 cells. Chromosomes are stacked from top left to bottom right in order (from chr1 to chrX). (lower panels) Enlarged intra-chromosomal interaction heatmaps of chr3. Color axis is shown on the right. b Pie chart showing the compartment changes between the control and ATRA-treated HL-60 cells. “Unchanged” indicates that the compartments are identical in both cells. “A to B” indicates that the compartments have an A pattern in the control cells and a B pattern in the ATRA-treated cells. “B to A” indicates that the compartments have a B pattern in the control cells and an A pattern in the ATRA-treated cells. “Undefined” indicates regions in which the compartment pattern could not be defined (projection of Hi-C first principal component equals zero). c Venn diagram showing that more than 90% of the TAD boundaries are stable in the control and ATRA-treated cells