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. 2018 Jan 26;9(2):132. doi: 10.1038/s41419-017-0150-0

Fig. 3. Hepatocellular necrosis is ameliorated by the application of CD95Fc.

Fig. 3

Liver injury was induced by 45 min of warm ischemia of the median and left lateral liver lobe after prior application of two IV injections of CD95Fc (30 mg/kg) or the same volume of IgG (30 mg/kg) antibody at 12 h and at 30 min before ischemia. After 12 h and again after 24 h of reperfusion, liver tissue was harvested and processed for histopathology. Representative H&E-stained liver sections (×100 magnification, areas of necrosis marked with an asterisk). a sham, reperfusion 12 h; b IgG, reperfusion 12 h; c CD95Fc, reperfusion 12 h; d sham, reperfusion 24 h; e IgG, reperfusion 24 h; f CD95Fc, reperfusion 24 h. g Area of necrosis (% of area) (mean ± S.D., n = 6. *p < 0.0001, MANOVA, between-subject-effect compared to IgG, time points 12 and 24 h were considered as repeated measurements)