Fig. 1. Effect of the MEK inhibitors U0126 and PD901 on the cell proliferation and apoptosis of K-Ras mutant HuCCT1 and KKU213 human CCA cell lines.

a, b Cell proliferation and apoptosis rates of HuCCT1 cells treated with U0126 (a) or PD901 (b). c, d Cell proliferation and apoptosis rates of KKU213 cells treated with U0126 (c) or PD901 (d). Tukey Kramer test, p < 0.05, a vs. untreated cells; b vs. DMSO-treated cells; c vs. PD901 0.1 µM