Fig. 1. UHRF1 depletion sensitizes retinoblastoma cells to chemotherapeutic drugs.

a–c Dose–response study showing the relative sensitivity to drugs. Stable control-knockdown (shCTL) and UHRF1-knockdown (shUHRF1) Y79 cells were exposed to various concentrations of chemotherapeutic drugs for 48 h, as indicated. d–f Time-course study showing the relative sensitivity to drugs. Cells were treated with 10 µM etoposide (d), 0.5 µM camptothecin (e), and 100 µM carboplatin (f) for the indicated time. The results at each data point are shown as the mean ± standard deviation (SD) of % fold changes from three independent experiments, relative to the cell viability in untreated group. *P < 0.05, **P < 0.01