Fig. 2. TAK-165 in combination with AC220 induces cell death in breast, AML, and breast triple negative cancer cell lines.

a Cell viability (%) of breast cancer (Bcap-37, MCF-7 and Sum159), b AML (HEL, MOLM-14 and OCI-AML3), c triple negative breast cancer (Sum149 and HCC1937), and d non-cancer cell lines (MDCK and MRC-5 SV2) treated with TAK-165 (125 nM) and AC220 at 2 different concentrations (1 and 2 μM) for 24 h. Viability was determined using Sulforhodamine B assay (Breast cancer cells) and CellTiter-Glo® Luminescent assay (AML, breast triple negative and non-cancer cell lines). In all the experiments, treatment groups were compared with control group, unless otherwise indicated (n = 3). Bars: Mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001