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. 2018 Jan 24;7(1):8. doi: 10.1038/s41389-017-0025-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a GST-catalyzed conjugation of ethacrynic acid; b A conjugate of ethacrynic acid and glucosamine (EAG) reacts with GSH and inhibits GSTs; c Ethacraplatin is a Pt(IV)-complex compound which contains two ethacrynic acid moieties. When exposed to GSTs, this compound inhibits the enzyme and liberates cisplatin; d NBDHEX and its MC3181 derivative are GST inhibitors that bind the enzyme H-site and are conjugated by GSH leading to the formation of a stable σ complex; e Auranofin structure and its inhibitory effect on GSTs; f Ezatiostat (TLK199) is a GSH analogue that exerts its inhibitory effects on GSTs through G-site binding; g Piperlongumine is hydrolized inside cells and forms a conjugate with GSH that exerts inhibition of GST acitivity