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. 2018 Jan 24;7(1):8. doi: 10.1038/s41389-017-0025-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Bioconversion of canfosfamide in an active alkilating metabolite played by GSTP1-1; b synthesis and bioconversion played by GST of a metformin sulfonamide prodrug; c GSH conjugation with nitric oxide releasing agents to form diazeniumdiolate anion and subsequent release of two NO molecules; d Release of active doxorubicin by GST sulfomidase activity played on nitrobenzenesulfonyl analogues