Table 1.

GST allelic variants associated with cancer risk and other diseases

Gene	Allelic variant	Modification	OMIM number	Diseases	Ref.
GSTM1	GSTM1*O	Gene deletion	138350	Uterine leiomyoma, hypertension, oral leukoplakia, prostate cancer, chronic myeloid leukemia, breast cancer, epilepsy	35–37, 39–41, 61
GSTT1	GSTT1*O	Gene deletion	600436	Uterine leiomyoma, hypertension, oral leukoplakia, brain tumour, breast cancer, coronary heart disease, psoriasisa, epilepsy	35–38, 40,43, 44
GSTP1	GSTP1*B	Ile105Val	134660.0002	chronic myeloid leukemia, Parkinson’s disease, Amyotrophic lateral sclerosis	39,56, 66
	GSTP1*C	Ile105Val/Ala114Val	134660.0003	Alzheimer’s disease, Parkinson’s disease	52, 56
	GSTP1*D	Ala114Val	—	Brain tumour, Parkinson’s disease	38, 56
GSTA1	GSTA1*B	-69(C/T), mutation promoter	138359	Psoriasisb	44
GSTO1	GSTO1*B	Glu155 deletion	605482	Alzheimer’s disease	53
GSTO2	GSTO2*B c	Asn142Asp	612314	Breast cancer	42
	GSTO2*C c	Ala183Gly	—	Spinocerebellar ataxia type 2	65

OMIM Online Mendelian Inheritance in Man

^a in association with GSTA1*A

^b in association with GSTT1*A

^c Allelic variants were identified as B and C in this work following the nomenclature by Townsend and Tew³⁴