The pharmacokinetic profile of droxidopa was studied in healthy elderly volunteers.

Food effects were examined in a single-dose administration study, and the pharmacokinetic profiles of droxidopa and key metabolites associated with multiple daily dosing were determined.

Findings suggest that the absorption of a single dose of droxidopa is slowed after a high-fat/high-calorie meal [including an average 20% decrease in area under the plasma concentration–time curve (AUC) versus patients taking droxidopa under fasted conditions] and that the pharmacokinetic parameters of droxidopa are similar after single and 3-times-daily dosing.