Fig. 2.

Expanded mitochondrial network structures. Central aspects of bioenergetic, metabolic and macromolecular structures in Fig. 1 can be expanded to include subnetwork structures and elements. A. The central energy currencies support biosynthesis and processing of macromolecules within the physical spaces of mitochondria. B. Systems for post-translational modification of proteins integrate bioenergetic and metabolic functions with the activities, interactions and trafficking of macromolecules. C. Transport systems utilize energy currencies to maintain macromolecular, metabolic and ionic composition of the mitochondrial compartments.