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. Author manuscript; available in PMC: 2018 Mar 2.
Published in final edited form as: Free Radic Biol Med. 2018 Jan 6;116:31–40. doi: 10.1016/j.freeradbiomed.2018.01.005

Fig. 5.

Fig. 5

Transcriptome-metabolome network structures linked to mitochondrial respiratory and oxidative stress measures in SH-SY5Y cells. A. Proton leak-dependent oxygen consumption rate (OCR) as a function of Mn concentration in the culture medium measured by Seahorse Bioenergetics Analyzer. B. Mitochondrial H2O2 production rate as a function of Mn concentration measured by MitoPy1. C. Top hubs of transcriptome-metabolome interaction networks associated with OCR and other mitochondrial oxidative stress measures. Original data on mitochondrial oxidative stress and OCR measures from Fernandes et al. [75].