Table 3.

Multivariate Cox proportional hazards regression analysis for prediction of DFI, DMFI and OS

Parameter	DFI		DMFI		OS
	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)
ctDNA	<0.0001		<0.0001		0.005
Undetectable		1.00		1.00		1.00
Detectable		3.26 (1.83–5.83)		3.45 (1.88–6.34)		2.50 (1.32–4.74)
ECOG	0.02		0.01		0.02
0		0.52 (0.30–0.89)		0.46 (0.25–0.82)		0.47 (0.25–0.87)
1		1.00		1.00		1.00
Disease stage	0.02		0.02
II		0.46 (0.25–0.87)		0.45 (0.23–0.89)
IIIa		0.38 (0.19–0.76)		0.34 (0.16–0.74)
IIIb		0.66 (0.39–1.12)		0.59 (0.34–1.04)
IIIc		1.00		1.00