Figure 1.

(A) Overall survival (OS) according to receipt of whole brain radiotherapy before extracranial progression (per-protocol analysis). Patients were censored at the time of follow up or extracranial progression. Thus, this plot displays the survival effect of WBRT among patients without evidence of extracranial progression (estimated from all patients, using their extracranial progression free interval). (B) Landmark analysis of OS according to the receipt of whole brain radiotherapy (WBRT). The landmark represented the absence of extracranial progression at 6 months. Patients with events before 6 months were excluded from analysis.