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(A) Progression-free survival after anti-EGFR plus irinotecan-based therapy in the second or third-line setting in RAS wild-type metastatic colorectal cancer patients according to method of RAS mutation detection (SoC tumor tissue at baseline N =50 or ctDNA plasma before therapy N =47). (B) Survival in metastatic setting according to RAS mutant allele fraction by ctDNA plasma. MAF of 0.1 corresponds to a percentage of mutant alleles of 10%. SoC, standard of care.
