Table 1.

Concordance between tumor-tissue and ctDNA analysis (N = 146)

ctDNA analysis		Tumor-tissue analysis SoC			Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
		KRAS mut	NRAS mut	WT
BEAMing	KRAS mut	40	0	6	89	90	84	93
	NRAS mut	0	8	3
	WT	4	2	83
	Total	44	10	92
		Tumor-tissue analysis BEAMinga			85	91	89	88
BEAMing	KRAS mut	42	0	4
	NRAS mut	0	9	2
	WT	7	2	64
	Total	49	11	70
Tumor-tissue analysis		Tumor-tissue analysis SoC			94	88	85	96
BEAMing	KRAS mut	42	0	7
	NRAS mut	0	9	2
	WT	2	1	67
	Total	44	10	76

^aTumor-tissue analysis with BEAMing was carried out in 130 samples.

WT, wild type; SoC, standard of care; ctDNA, circulating tumor DNA; PPV, positive predictive value; NPV, negative predictive value.