Table 2.
Patient treatment and response by prognostic risk group within age subsets
| All patients | Limited |
Advanced |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| N (%) |
N (%) |
N (%) |
|||||||
| Total | Age | Age | P | Total | Age | Age | P | ||
| < 18 year | 18–25 year | < 18 year | 18–25 year | ||||||
| Total | 209 | 78 | 20 (26) | 58 (74) | 131 | 35 (27) | 96 (73) | ||
| Treatment site | |||||||||
| Paediatric centre | 35 (17) | ||||||||
| Adult centre | 174 (83) | ||||||||
| PET at diagnosis | |||||||||
| Yes | 51 (24) | 18 (23) | 13 (65) | 5 (9) | <0 .001 | 33 (25) | 23 (66) | 10 (10) | <0 .001 |
| No | 158 (76) | 60 (77) | (35) | 53 (91) | 98 (75) | 12 (34) | 86 (90) | ||
| RT in primary therapy | |||||||||
| Yes | 43 (21) | 19 (24) | 2 (10) | 17 (29) | 0 .08 | 24 (18) | 6 (17) | 18 (19) | 0 .83 |
| No | 166 (79) | 59 (76) | 18 (90) | 41 (71) | 107 (82) | 29 (83) | 78 (81) | ||
| Response | |||||||||
| CR | 192 (92) | 78 (100) | 20 (100) | 58 (100) | – | 114 (87) | 26 (74) | 88 (92) | 0 .01 |
| PR | 10 (5) | 0 | 0 | 0 | 10 (7) | 4 (11) | 6 (6) | ||
| SD | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| PD | 7 (4) | 0 | 0 | 0 | 7 (5) | 5 (14) | 2 (2) | ||
| Timing of relapse | |||||||||
| Primary progressive | 11 (35) | 1 (17) | 0 | 1 (25) | 0 .22 | 10 (40) | 6 (75) | 4 (24) | 0 .03 |
| Early relapse | 12 (39) | 3 (50) | 2 (100) | 1 (25) | 9 (36) | 2 (25) | 7 (41) | ||
| Late relapse | 8 (26) | 2 (33) | 0 | 2 (50) | 6 (24) | 0 | 6 (35) | ||
| 5-year PFS ± SE (%) | 85 ± 3 | 92 ± 3 | 90 ± 7 | 93 ± 3 | 0 .65 | 80 ± 4 | 77 ± 7 | 81 ± 4 | 0 .38 |
| 5-year OS ± SE (%) | 97 ± 1 | 100 | 100 | 100 | – | 95 ± 2 | 90 ± 6 | 97 ± 2 | 0 .17 |
Analysis of the difference in treatment and response based on age for limited and advanced stage prognostic groups. CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease.