Table 2.
Average decrease in number of patients enrolled per 30-patient DEC as a result of the interim futility analysis for the six scenarios of toxicity/efficacy curves in Figure 2 under each dose-assignment and efficacy analysis, stratified by the efficacious DECs (left) and inefficacious DECs (right)
| Efficacious DECs |
Inefficacious DECs |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CRM | Global | Local | CRM | Global | Local | CRM | Global | Local | CRM | Global | Local | |
| Set 1 | Set 2 | Set 1 | Set 2 | |||||||||
| Model | 0.4 | 1.9 | 2.4 | 2.0 | 4.4 | 4.8 | 7.0 | 6.9 | 7.4 | 6.9 | 6.9 | 7.2 |
| Empiric | 1.5 | 2.0 | 3.5 | 3.6 | 4.5 | 6.0 | 8.8 | 7.0 | 8.0 | 8.6 | 7.0 | 7.7 |
| Set 3 | Set 4 | Set 3 | Set 4 | |||||||||
| Model | 0.4 | 0.5 | 0.9 | 1.0 | 1.8 | 2.9 | 3.7 | 2.9 | 4.2 | 2.9 | 2.7 | 4.1 |
| Empiric | 0.9 | 0.4 | 0.8 | 1.4 | 1.6 | 2.4 | 3.8 | 2.5 | 3.1 | 3.4 | 2.4 | 3.1 |
| Set 5 | Set 6 | Set 5 | Set 6 | |||||||||
| Model | 0.8 | 2.6 | 3.2 | 1.2 | 2.6 | 2.4 | 7.1 | 6.9 | 7.0 | 7.1 | 6.9 | 6.2 |
| Empiric | 2.1 | 2.7 | 4.3 | 2.3 | 2.8 | 3.8 | 9.0 | 7.1 | 7.6 | 8.4 | 7.1 | 6.6 |