Table 1.

CTCAE (version 4.0) vomiting item, corresponding patient reported version and CTCAE and UKONS severity grading (0–3)

CTCAE (version 4.0) Vomiting item	PRAE item Have you been sick (vomited)?	CTCAE Grade	CTCAE Version 4.0 General description of severity grading	UKONS
N/A	N/A	0	N/A	No problem reported and no advice needed.
1–2 episodes (separated by 5 min) in 24 h	I have vomited 1–2 times in a 24-h period	1	Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated	Mild problem not requiring medical attention, self-management is appropriate
3–5 episodes (separated by 5 min) in 24 h	I have vomited 3–5 times in a 24-h period	2	Moderate; minimal, local or non-invasive intervention indicated; limiting age-appropriate instrumental ADL	Potentially serious problem, may require medical attention
≥6 episodes (separated by 5 min) in 24 h; tube feeding, TPN or hospitalization indicated	I have vomited six or more times in a 24-h period	3	Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self- care ADL	Potential medical emergency, requires urgent medical review

ADL, activities of daily living; instrumental ADL (preparing meals, shopping for groceries or clothes, using the telephone, managing money, etc.), self-care ADL (bathing, dressing and undressing, feeding self, using the toilet, taking medications and not bedridden).