Figure 3.

Generalized overview showing the proposed ctDNA incorporation into the hallmark cancer staging system as TNMB. Each categorical column indicates the anatomical valuation criteria by row for advancing cancer stage, thus reflecting tumor progression. Advancing genomics technologies promise to reveal this previously hidden anatomical indicator—ctDNA— to more accurately stage and treat cancers. Information for TNM staging in this figure derived from the TNM Classification of Malignant Tumours by UICC (7th Edition) [103].