Skip to main content
. 2017 Aug 29;28(10):2595–2605. doi: 10.1093/annonc/mdx416

Figure 2.

Figure 2.

PDX models preserve the histopathology and genetic landscape of the parental tumor. (A) Histology (H&E) of PDX models at early passage (2 or 3) and the parental tumor from which they were established. Four primary lesions and matching PDX models from four different tumor types are shown. ×10 magnification. (B) Histology (H&E) of four PDX models at passage 0 (first transplantation into immunodeficient mice) and passage 4. Four PDX models from 4 different tumor types are shown. ×10 magnification. (C) Background mutation rates from WES analysis of 237 early passage PDX models of different tumor types (109 colorectal, 30 ovarian, 38 lung, 30 head and neck and 30 breast cancers) and samples from the TCGA database (224 colorectal, 316 ovarian, 227 lung, 306 head and neck and 772 breast cancers). (D) Spectrum of specific base-pair substitutions in PDX models and TCGA samples across different cancer types analyzed. (E) Venn diagram summarizes single-nucleotide mutations concurrently detected by WES in four primary tumors and their matched early passage PDX counterparts. (F) Spectrum of specific base-pair substitutions in 4 PDX models and parental tumor from which they were established.