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. 2018 Feb 27;13:1119–1137. doi: 10.2147/IJN.S147464

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© 2018 Pan et al. This work is published and licensed by Dove Medical Press Limited

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Synthetic route of folate-conjugated amphiphilic poly(β-thiopropionate).

Abbreviations: FA, folic acid; TEA, trimethylamine; DCM, dichloromethane; NMP, N-methyl-2-pyrrolidone; EDC, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide; DMAP, 4-dimethylaminopyridine; PEG, polyethylene glycol; MeOH, methanol; CY, cysteamine; TEG, tetra (ethylene glycol); CY-TEG, cysteamine capped tetra (ethylene glycol); DDA, dodecylamine; APT, 5-aminopentanol; CY-TEG-PEG-DDA-APT, poly (beta-thiopropionate) amphiphilic copolymer.