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. 2018 Jan 19;9(13):11126–11144. doi: 10.18632/oncotarget.24277

Figure 6. Model for Sema4D+ve/high tumor cells with a fibrotic peri-tumoral stromal phenotype versus Sema4D-ve/low tumor cells with Sema4D+ve/high TAIs.

Figure 6

(A) Sema4D+ve/high tumor cells induce increased production of TGF-β1 by tumor cells and collagen deposition by fibroblasts in the ECM. (B) Sema4D-ve/low tumor cells with inflamed stroma. Sema4D-ve/low tumors has decreased level of TGF-β1 production, less fibrotic and more into the loose peri-tumoral stroma with increased infiltrate of Sema4D+ve/high TAIs. TAIs: Tumor Associated Inflammatory cells.