Figure 5. Ctnnb1^{CA hep} mice display severe disturbances in carbohydrate metabolism.

No difference in blood glucose levels between Ctnnb1^{CA hep} and WT littermates was detectable (A). PAS staining shows severely decreased levels of glycogen in Ctnnb1^{CA hep} mice (B). mRNA levels of key enzymes in glucose metabolism including Phosphofructokinase (Pfkl, C), liver specific glycogen phosphorylase (Pygl, D) and fructose 1,6-bisphosphatase (Fbp1, E) were significantly down-regulated in livers of Ctnnb1^{CA hep} mice. Glycogen synthase 2 (Gys2, F) was not deregulated on mRNA level. Western blot analysis revealed down-regulation of main glucose transporter GLUT2 (SLC2A2) in livers of Ctnnb1^{CA hep} mice compared to WT controls (G).