Figure 1. Plasma levels of immune-related mediators in HNSCC patients undergoing CMT.

Peripheral blood was collected from HPV⁺ HNSCC patients before, during and after CMT treatment completion. Plasma samples were analyzed using for Luminex assay to assess the cytokine/chemokine levels. Different symbols were used to indicate samples from various patients; the HPV-positive patients were shown in color (red, blue and green). Fold changes of IL-6 (A), TNFɑ (B), VEGF (C), CCL2 (D), and IFNγ (E), AND IL-12 (F) are shown; p values were obtained using paired student t-test (baseline n=14, ^*p<0.05, ^**p<0.005, ^***p<0.0005).