Figure 5. CMT results in the upregulation of PD-L1/CD274on HNSCC-associated MDSCs.

(A) mRNA expression levels of CD274 in PBMCs in patients undergoing CMT at the beginning and at the second week of therapy were compared using Nanostring analysis (n = 6). Protein expression level of CD274 on CD33⁺ myeloid cells (B), PMN-MDSC (C), and M-MDSC (D) were analyzed using flow cytometry. Paired student t-test; ^*p<0.05, ^**p<0.005, ^***p<0.0005.