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. 2017 Dec 15;9(13):10987–10994. doi: 10.18632/oncotarget.23743

Figure 2. Cytogenetic findings (case 11).

Figure 2

(A). Chromosomal analysis shows a karyotype of 46,XY,t(4;12)(q12;p13)[20]. (B). FISH analysis using PDGFRA tri-color break-apart probe (FIP1L1 in green, CHIC2 in red and PDGFRA in aqua) shows 1 triple fusion, 1 green-red fusion, and 1 separate aqua signal, which confirms PDGFRA gene rearrangement (translocation of aqua signal to derivative chromosome 12). (C). FISH analysis using ETV6 dual-color break-apart probe shows ETV6 gene rearrangement (translocation of red signal to derivative chromosome 4).