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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: J Chem Neuroanat. 2017 Sep 2;93:2–15. doi: 10.1016/j.jchemneu.2017.08.004

Table 1. Variability in numerical estimates between quantitative studies.

Nervous System Structure Species Method Numerical Ranges References
Cerebral cortex Human HIS 0.6-16.5 ×109 Haug, 1986
Dorsal root ganglion, Lumbar 4 Rat HIS 5.3-12.5 ×103 Schmalbruch, 1987
Dorsal root ganglion, Lumbar 5 Rat HIS 2.0-14.8 ×103 Schmalbruch, 1987
Dorsal root ganglion, Lumbar 6 Rat HIS 4.1-14.1 ×103 Schmalbruch, 1987
Purkinje cells Rat STE 2.1-6.1 ×105 Guillery & Herrup, 1997
Cerebral cortex Human STE 13.7-22.8 ×109 Peters et al., 1998
Dentate gyrus Mouse strains STE 0.38-0.94 ×106 Abusaad et al., 1999
Pyramidal cell layer Mouse strains STE 0.43-0.93 ×106 Abusaad et al., 1999
Dorsal root ganglion, Lumbar 5 Rat STE 14.1-19.2 ×103 Tandrup et al., 2004
Hippocampus Human STE 22.6-40.4 ×106 Korbo et al., 2004
Granule cells (Dentate gyrus) Rat STE 1.2-1.55 ×106 Schmitz & Hof, 2005
Pyramidal cells (CA1-3) Rat STE 615-930 ×103 Schmitz & Hof, 2005
Cerebral cortex Rhesus monkey STE 1.35-2.95 ×109 Charvet et al., 2015
Cerebral cortex Rhesus monkey IF 0.825 ×109 Charvet et al., 2015
Purkinje cells Rat STE 2.1-6.1 ×105 Herculano-Houzel et al., 2015
Lateral geniculate nucleus Human STE 1.99-3.48 ×106 Herculano-Houzel et al., 2015
Neocortex Human IF 12.7-16.3 ×109 Herculano-Houzel et al., 2015
Cerebellum Human IF 54-65 ×109 Herculano-Houzel et al., 2015
Whole Brain Human IF 67.3-86 ×109 Herculano-Houzel et al., 2015
Purkinje cells Human HIS 0.88-26 ×106 von Bartheld et al., 2016
Purkinje cells Human STE 15.4-30.5 ×106 von Bartheld et al., 2016
Dorsomedial thalamic nucleus (Schizophrenia) Human STE 0-40% loss Dorph-Petersen & Lewis, 2017
Spiral ganglion (Young Adult) Human HIS 23.1-33.7 ×103 Kaur et al., 2018
Spiral ganglion (Young Adult) Human STE 26.7-41.7 ×103 Kaur et al., 2018

HIS, histology (profile counting = 2D Method); IF, isotropic fractionator; STE, stereology (= 3D Method)