Table 1. Variability in numerical estimates between quantitative studies.
Nervous System Structure | Species | Method | Numerical Ranges | References |
---|---|---|---|---|
Cerebral cortex | Human | HIS | 0.6-16.5 ×109 | Haug, 1986 |
Dorsal root ganglion, Lumbar 4 | Rat | HIS | 5.3-12.5 ×103 | Schmalbruch, 1987 |
Dorsal root ganglion, Lumbar 5 | Rat | HIS | 2.0-14.8 ×103 | Schmalbruch, 1987 |
Dorsal root ganglion, Lumbar 6 | Rat | HIS | 4.1-14.1 ×103 | Schmalbruch, 1987 |
Purkinje cells | Rat | STE | 2.1-6.1 ×105 | Guillery & Herrup, 1997 |
Cerebral cortex | Human | STE | 13.7-22.8 ×109 | Peters et al., 1998 |
Dentate gyrus | Mouse strains | STE | 0.38-0.94 ×106 | Abusaad et al., 1999 |
Pyramidal cell layer | Mouse strains | STE | 0.43-0.93 ×106 | Abusaad et al., 1999 |
Dorsal root ganglion, Lumbar 5 | Rat | STE | 14.1-19.2 ×103 | Tandrup et al., 2004 |
Hippocampus | Human | STE | 22.6-40.4 ×106 | Korbo et al., 2004 |
Granule cells (Dentate gyrus) | Rat | STE | 1.2-1.55 ×106 | Schmitz & Hof, 2005 |
Pyramidal cells (CA1-3) | Rat | STE | 615-930 ×103 | Schmitz & Hof, 2005 |
Cerebral cortex | Rhesus monkey | STE | 1.35-2.95 ×109 | Charvet et al., 2015 |
Cerebral cortex | Rhesus monkey | IF | 0.825 ×109 | Charvet et al., 2015 |
Purkinje cells | Rat | STE | 2.1-6.1 ×105 | Herculano-Houzel et al., 2015 |
Lateral geniculate nucleus | Human | STE | 1.99-3.48 ×106 | Herculano-Houzel et al., 2015 |
Neocortex | Human | IF | 12.7-16.3 ×109 | Herculano-Houzel et al., 2015 |
Cerebellum | Human | IF | 54-65 ×109 | Herculano-Houzel et al., 2015 |
Whole Brain | Human | IF | 67.3-86 ×109 | Herculano-Houzel et al., 2015 |
Purkinje cells | Human | HIS | 0.88-26 ×106 | von Bartheld et al., 2016 |
Purkinje cells | Human | STE | 15.4-30.5 ×106 | von Bartheld et al., 2016 |
Dorsomedial thalamic nucleus (Schizophrenia) | Human | STE | 0-40% loss | Dorph-Petersen & Lewis, 2017 |
Spiral ganglion (Young Adult) | Human | HIS | 23.1-33.7 ×103 | Kaur et al., 2018 |
Spiral ganglion (Young Adult) | Human | STE | 26.7-41.7 ×103 | Kaur et al., 2018 |
HIS, histology (profile counting = 2D Method); IF, isotropic fractionator; STE, stereology (= 3D Method)