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. Author manuscript; available in PMC: 2019 Mar 2.
Published in final edited form as: Hepatology. 2018 Jan 2;67(2):676–689. doi: 10.1002/hep.29504

Figure 7. Activation of the AGE-RAGE signaling enhances cholangiocyte proliferation and expression of IL6 and TGFB1.

Figure 7

(A) Representation of subcore genes (red) in the AGE-RAGE pathway (downloaded from KEGG pathway database). (B) Graph showing that genes in the AGE-RAGE pathway are enrichment in individual diseases, but not in intrahepatic cholestasis (IHC) or polycystic liver disease (PLD). Enrichment scores are represented as – log10, with a threshold of 1.3 as the cut-off for significance (P < 0.05; green line). (C) H69 cholangiocyte proliferation by the MTS assay after 48 hours of culture with PBS control, HMGB1 or HMGB1 plus RAGE Fc protein. (D) IL6 and TGFB1 mRNA expression in H69 cells. Expression was normalized against GAPDH. Values as mean ± SD, N=3; *P < 0.05, **P < 0.01, ***P < 0.001