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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Trends Genet. 2017 Dec 27;34(3):197–208. doi: 10.1016/j.tig.2017.12.004

Figure 1. Fluorescent image and conceptual structure of PNNs.

Figure 1

(A) A neuron expressing parvalbumin (red) covered by a PNN as visualized by WFA fluorescent staining. Scale bar, 3 μm. (B) Structural components and regulators of PNN structure: hyaluronan, tenascin-R, hyaluronan and proteoglycan link proteins (HAPLN1, HAPLN4), the lecticans (aggrecan, brevican, neurocan, and versican), and enzymes that degrade the extracellular matrix (MMP and ADAMTS proteins).