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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Trends Genet. 2017 Dec 27;34(3):197–208. doi: 10.1016/j.tig.2017.12.004

Figure 2. Brain regions in which PNNs are remodeled or regulate addiction behaviors.

Figure 2

(A) Saggital view of rat or mouse brain showing areas in which PNNs have been demonstrated to change in response to drug exposure and/or in which PNNs have been degraded by microinjection of chondroitinase ABC (ChABC) and animals tested for CPP or drug self-administration. Black arrow shows locations in which ChABC has been injected. Note that the insula, a cortical area that shows an increase in PNNs after ethanol exposure, is not shown here. (B) Experimental design of CPP and drug self-administration experiments showing when ChABC was injected relative to testing animals for either CPP or reinstatement of drug-seeking behavior. Abbreviations: PFC, prefrontal cortex (includes prelimbic, medial prefrontal, and orbitofrontal); AMY, amygdala; HIPP, hippocampus; Hyp, hypothalamus; VTA, ventral tegmental area. References are indicated in brackets.