Table 1.
Patient Characteristics by Nutrition Group
| Bodyweight | P-Value# | ||||||
|---|---|---|---|---|---|---|---|
|
| |||||||
|
Characteristic Mean (±SD) or N (%) |
Malnourished (N=214) |
Normal Bodyweight (N=570) |
Obese (N=120) |
Overall |
Malnourished vs. Normal | Normal vs. Obese | Malnourished vs. Obese |
| Age at Diagnosis (years), mean±SD | 2.70±4.50 | 5.70±5.95 | 9.00±6.34 | <0.001 | <0.001 | <0.001 | <0.001 |
| Gender (male) | 101 (47.2%) | 293 (51.4%) | 72 (60%) | 0.080 | |||
| Height-for-age z-score | 0.27±1.98 | −0.20±1.44 | −0.67±2.77 | <0.001 | 0.001 | 0.010 | <0.001 |
| Weight-for-age z-score | −1.77±1.75 | −0.29±1.24 | 1.81±2.21 | <0.001 | <0.001 | <0.001 | <0.001 |
| BMI | 13.25±1.49 | 17.13±3.10 | 29.90±13.20 | <0.001 | <0.001 | <0.001 | <0.001 |
| Race | 0.832 | ||||||
| White | 127 (59.9%) | 328 (58.8%) | 58 (48.7%) | ||||
| Black | 42 (19.8%) | 108 (19.4%) | 39 (32.8%) | ||||
| Hispanic | 23 (10.8%) | 89 (15.9%) | 16 (13.4%) | ||||
| Other | 22 (10.2%) | 45 (5.9%) | 7 (5.0%) | ||||
| Etiology | 0.164 | ||||||
| Idiopathic | 174 (81.3%) | 441 (77.5%) | 100 (83.3%) | ||||
| Myocarditis | 29 (13.6%) | 97(17.0%) | 9 (7.5%) | ||||
| Familial | 11 (5.1%) | 31 (5.4%) | 11 (9.2%) | ||||
| Family History of Cardiomyopathy* | 27 (21.1%) | 80 (23.5%) | 26 (36.1%) | 0.044 | 0.595 | 0.023 | 0.018 |
| Family History of Sudden Death | 12 (8.9%) | 44 (13.1%) | 13 (17.1%) | 0.207 | |||
| HF at Diagnosis | 171 (79.9%) | 396 (69.7%) | 81 (68.6%) | 0.012 | 0.005 | 0.813 | 0.028 |
| Anti-heart Failure Therapy | 193 (91.0%) | 476 (85.6%) | 99 (83.2%) | 0.072 | |||
*
Family history is defined in this Registry as any family member with a known cardiomyopathy and captured separately from familial dilated cardiomyopathy, which is defined as genetic cause of cardiomyopathy. SD-standard deviation, BMI-body mass index, FamHx-family history, HF-heart failure.
#
Pair-wise comparison P values <0.017 are considered statistically significant, applying post hoc Bonferroni correction