Skip to main content
. Author manuscript; available in PMC: 2019 Feb 27.
Published in final edited form as: ACS Nano. 2018 Jan 31;12(2):1250–1261. doi: 10.1021/acsnano.7b07384

Figure 2. Wnt5a is a key molecule controlling the immunosuppressive desmoplastic TME.

Figure 2

(A) Figure legend depicting Wnt5a functions on both DCs and Fibroblasts within TME. Wnt5a is highly expressed among BRAF-mutant melanoma, compared to BRAF-wild-type, in both clinical (panel B, TCGA database, n = 368) and murine samples (panel C, Western blot, n = 3). (D) High level of Wnt5a correlates with poorer patient overall survival. n = 29. (E) Masson’s trichrome staining illustrating BRAF-mutant melanoma with desmoplastic collagen-rich TME (black arrows), compared to wild-type in both human and mouse specimens. Scale bar indicates 300 µm. n = 3. *: p < 0.05, **: p < 0. 01.