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. 2018 Feb 26;9:136. doi: 10.3389/fphar.2018.00136

Figure 1.

Figure 1

Dose response curves of sanguinarine. (A) Cytotoxicity of sanguinarine toward drug-sensitive parental CCRF-CEM tumor cells and their P-glycoprotein (MDR1/ABCB1)-expressing, multidrug-resistant subline, CEM/ADR5000. (B) Cytotoxicity of sanguinarine toward HEK293 cells and their ABCB5-transfectant subline, HEK293/ABCB5 as determined by resazurin assays. (C) Cytotoxicity of sanguinarine toward MDA-MB-231-pc DNA cells and their BCRP-transduced subline, MDA-MB-231-BCRP as determined by resazurin assays. (D) Cytotoxicity of sanguinarine toward HCT116 p53+/+ cells and their p53−/− knockout subline, HCT116 p53−/− as determined by resazurin assays. (E) Cytotoxicity of sanguinarine toward U87MG cells and their EGFR-transduced subline U87MGΔEGFR, as determined by resazurin assays. (F) Cytotoxicity of sanguinarine toward human peripheral mononuclear cells, as determined by resazurin assays.